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Sildenafil Vs Tadalafil
January 21, 2022
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Sildenafil Vs Tadalafil

You’ve heard of Viagra and Cialis, possibly even Levitra. These are commonly prescribed treatments for erectile dysfunction (ED). Sildenafil vs tadalafil is always a trending question for treating the ED/Impotence. But which one is best? And are there any differences between them? The simple answer is NO, The best treatment for ED is the one that is best for you. Sildenafil (Viagra) and tadalafil (Cialis) are the most commonly prescribed medications for ED and are equally safe and effective. In most cases, lifestyle and cost will help you decide between them.

What are Viagra, Cialis, and Levitra?

Sildenafil (Viagra), tadalafil (Cialis), and vardenafil (Levitra) belong to a class of drugs known as PDE₅ inhibitors. To understand how they work, we’ll need a quick 101 on erections. For an erection to happen, a chemical called nitric oxide (NO) sends a message to the tissues of the penis (in technical terms, the corpus cavernosum), which relaxes and fills with blood. The erection is ended by another messenger, PDE₅ (phosphodiesterase-5).

PDE₅ inhibitors slow the erection “off switch,” helping the erection last long enough for satisfying sex. (These medications do not help with turning erections “on.”)

Viagra, Levitra, and Cialis have all been proven to be safe and effective in the treatment of erectile dysfunction. The main differences between them are:

  • How they’re taken
  • How long they last
  • Side effects
  • Cost

For occasional use, most people start with sildenafil. For regular use, tadalafil can be a better fit. Some people prefer to alternate between medications, depending on their lifestyle and relationship status.

Viagra (sildenafil)

How to take it: Viagra shouldn’t be taken with food. Ideally, you should wait 1 to 2 hours after eating before taking it. If you really can’t wait, then try to stick to a light, low-fat meal. Fatty meals and alcohol can stop Viagra from working.

How fast it works: It can start to take effect in as little as 11 minutes, but usually, you’ll have to wait 1 hour before it reaches maximum effect. Then it keeps working for 3 to 5 hours.
Typical dose: The typical starting dose is 50 mg. If you’re getting side effects, it can be cut down to 25 mg. If it’s not working fully, it can be increased to 100 mg.

Cialis (tadalafil)

How to take it: Cialis is unaffected by food. It can be taken only when you need it, or regularly, every day.
How fast it works: It can start working in as quickly as 14 minutes, but you’ll have to wait 2 hours for it to reach the point when it’s most effective. Cialis stays in your body for about 17 hours, helping you with erections at any point in that time window.

Typical dose: The typical starting dose of Cialis for occasional use is 10 mg. It can be dropped to 5 mg or upped to 20 mg depending on how you respond. The daily dose for regular use is 2.5 mg.

Levitra (vardenafil)

How to take it: Like Viagra, Levitra shouldn’t be taken with food. Ideally, you should wait 1 to 2 hours after eating before taking it, but if that’s not possible, stick to a light, low-fat meal.

How fast it works: It can start working in as quickly as 14 minutes and reaches maximum effect after around 45 minutes. Then, it will keep working for 4 to 5 hours.

Typical dose: The typical starting dose of Levitra is 10 mg. It can be cut back to 5 mg or increased to a maximum of 20 mg.

What lasts longer, sildenafil or tadalafil?

Tadalafil lasts longer than sildenafil. Sildenafil has a duration of action of up to 4 hours, whilst tadalafil can last for up to 36 hours. This does not mean you will have a constant erection for the time periods each drug is active for. It means that you will achieve an erection upon sexual stimulation, for the time period that the drug is active. Tadalafil 2.5mg and 5mg (tadalafil daily) can be taken every day and is best suited for those that have more than 2 sexual encounters per week.

What works quicker, tadalafil or sildenafil?

Tadalafil works quicker than sildenafil by around 10-20 minutes on average. Sildenafil works around 30-60 minutes after it has been taken, whereas tadalafil works around 20-30 minutes after it has been taken. This can depend on the individual and how they respond to each treatment. Both sildenafil and tadalafil work best on an empty stomach. Taking tadalafil or sildenafil after a meal is likely to increase the length of time it takes to work.

What drugs interact with Cialis and Viagra?

Cialis

The breakdown and elimination of tadalafil from the body may be decreased by erythromycin, ketoconazole (Nizoral), itraconazole (Sporanox), indinavir (Crixivan), and ritonavir (Norvir). Therefore, these drugs may increase the levels of tadalafil in the blood. If these drugs are being used at the same time as tadalafil, the dose of tadalafil should be reduced to 10 mg every 72 hours when used as needed or 2.5 mg when used daily in order to avoid side effects from high levels of tadalafil.

Rifampin, carbamazepine (Tegretol, Tegretol XR, Equerto, Carbatrol), phenytoin (Dilantin, Dilantin-125), and phenobarbital may decrease blood levels of tadalafil, possibly reducing the effect of tadalafil.
Tadalafil exaggerates the increases in heart rate and lowering of blood pressure caused by nitrates, for example, nitroglycerin, isosorbide dinitrate (Isordil), isosorbide mononitrate (Imdur, Ismo, Monoket), nitroglycerin (Nitro-Dur, Transderm-Nitro) that are used primarily for treating heart pain (angina). In patients who take nitrates for angina, tadalafil could cause heart pain or possibly even a heart attack by exaggerating the increase in heart rate and the lowering of blood pressure. Therefore, tadalafil should not be used with nitrates.

Tadalafil also exaggerates the blood pressure lowering effects of some alpha-blocking drugs, for example, terazosin (Hytrin) primarily are used for treating high blood pressure or enlargement of the prostate (BPH). Individuals who take these alpha-blockers should be on a stable dose of the alpha-blocker before tadalafil is started. In such situations, tadalafil should be started at the lowest dose. If the patient is already taking tadalafil, the alpha-blocker should be started at the lowest dose. Combining tadalafil with alpha-blockers for the treatment of BPH is not recommended.

Tadalafil and alcohol both lower blood pressure. Therefore, combining tadalafil with alcohol may cause excessive drops in blood pressure and cause dizziness, headaches, and increased heart rate.

PDE5 inhibitors may affect platelet function and therefore prolong bleeding. Tadalafil should be used cautiously in patients with bleeding disorders or active ulcers. Tadalafil should not be combined with Adcirca (another form of tadalafil) or other PDE5 inhibitors, for example, vardenafil (Levitra) or sildenafil (Viagra, Revatio).

Viagra

Viagra increases the effects of blood pressure-lowering medications. It also increases the blood pressure lowering effects of nitrates, for example, isosorbide dinitrate (Isordil), isosorbide mononitrate (Imdur, Ismo, Monoket), nitroglycerin (Nitro-Dur, Transderm-Nitro) that are used primarily for treating angina. Patients taking nitrates should not receive Viagra.

Patients should not combine Viagra with other PDE5 inhibitors (for example, vardenafil [Levitra], tadalafil [Cialis]).

Cimetidine (Tagamet), erythromycin, ketoconazole (Nizoral), itraconazole (Sporanox), atazanavir (Reyataz), and mibefradil (Posicor) can cause marked increases in the amount of Viagra in the body.

Patients taking these medications should be observed carefully if sildenafil is used.
It is expected that rifampin will decrease blood levels of Viagra and probably reduce its effectiveness.

What has the least side effects, sildenafil or tadalafil?

Both tadalafil and sildenafil have a similar side-effect profile, but the side-effects of tadalafil may last longer, due to its larger window of action. However, sildenafil has a longer list of common side-effects that don’t appear to be as common in tadalafil. A common side-effect of both, include headache. You may also encounter facial flushing, which is when your face experiences a rapid sensation of warmth. Nasal congestion is another common side-effect of tadalafil and sildenafil.

How effective are Viagra, Cialis, and Levitra?

Sildenafil (Viagra), tadalafil (Cialis), and vardenafil (Levitra) all work equally well. There are no studies that directly compare them against each other, but a systematic review and meta-analysis of a few hundred studies found that all three medications result in successful penetrative sex in 65% to 80% of users with ED (compared to 30% with a sugar pill).

What are the common side effects of Viagra, Cialis, and Levitra?

The most common side effects of all PDE₅ inhibitors are:

Headache
Flushing
Nasal congestion
Indigestion
Vision changes
Muscle pain

With Viagra, there is a higher risk of vision changes than with Cialis. Three percent of people who take Viagra or sildenafil get the blue vision that lasts a few hours. On the other hand, Cialis has a slightly higher risk of muscle pain than Viagra and Levitra. Overall, users are not bothered much by the side effects of these medications, most of which do not last very long.

One serious side effect of all PDE₅ inhibitors is that they can lower your blood pressure. This won’t necessarily affect you, but if you also happen to be taking a blood pressure medication, it could be a problem. A sudden drop in blood pressure can make you dizzy, fall, blackout, or even cause a heart attack. The greatest danger is with nitrate medications such as nitroglycerin. If you take a nitrate drug, for angina or high blood pressure, you must never use sildenafil (Viagra), tadalafil (Cialis), or any similar medication.

How much do Viagra, Cialis, and Levitra cost?

At the time this page was last reviewed, these were the lowest GoodRx prices for a 30-day supply of a typical dose of each medication:

Sildenafil (generic Viagra): $13.28 for thirty 50 mg pills
Tadalafil (Generic Cialis): $17.07 for thirty 10 mg pills
Vardenafil (Levitra): $245.73 for thirty 10 mg pills

Which one has a higher success rate?

Both tadalafil and sildenafil have proven to have similar success rates in clinical trials, with both provings that they are effective in over 80% of those that use either drug. A study conducted by a hospital in China showed that tadalafil was preferred by men and that their partners also preferred the effect that tadalafil had over sildenafil. Another clinical trial carried out in Italy, showed that 73% of men preferred tadalafil over sildenafil.

Do you need a prescription for tadalafil or sildenafil?

Both tadalafil and sildenafil require a prescription, with the exception of Viagra Connect, which can be bought over the counter. To obtain sildenafil or tadalafil, you should visit your doctor, who will assess you before prescribing either drug. Erectile dysfunction treatment is not available on the NHS unless you have a certain medical condition, and you will need to pay the private cost of the treatment. There is no set fee, and pharmacies are able to charge their own price for these treatments. You are also able to buy ED treatment online, after completing an online questionnaire. You are able to purchase Viagra Connect from a local pharmacy, after having a consultation with the pharmacist. Alternatively, you are also able to buy Viagra Connect online, after answering questions relating to your health.

How do I know which one to use?

The only way to know whether you should use tadalafil or sildenafil is to try both treatments. You should speak to a pharmacist or doctor about which one to try. This can depend on various factors surrounding your sexual activity and preferences. If you have tried one tablet, you should try it a few times to allow your body to get used to it. If you aren’t experiencing the desired effects, you should try a higher strength the next time. If you have reached the maximum strength, and you have tried it a few times without the desired effect, you should speak to your doctor or pharmacist about trying an alternative.

Is Cialis 20mg equal to Viagra 100mg?

These strengths are both the highest doses available. Both are more likely to elicit a response, whereas the lower doses have not worked. However, they both need to be taken differently and differ in their duration of action.

Can you take tadalafil and sildenafil together?

You cannot take tadalafil and sildenafil together, or on the same day. Taking more than one ED treatment at the same time, or on the same day can cause unwanted and potentially harmful side effects. This can include, dizziness, nausea, indigestion, and a painful erection lasting longer than 4 hours. You can, however, use both treatments on different days.

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Where I can Buy Online Sildenafil and Tadalafil?

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So, sildenafil vs. tadalafil – which one is better?

On paper, tadalafil is better than sildenafil as it offers various advantages, mainly its longer duration of action. It also works faster than sildenafil, with milder side effects. Whilst both treatments are more effective on an empty stomach, tadalafil is not affected by food to the same extent as sildenafil is. However, the truth is that individuals vary in their responses to different treatments. Some men prefer sildenafil despite having tried tadalafil, and vice versa. You can see how our customers rate each treatment by looking at our sildenafil reviews and tadalafil reviews pages.

In our experience, men often prefer Tadalafil as it lasts longer, works faster, and can be taken with food. Having said that, some men find that Tadalafil does not suit them, so they prefer to stick with Sildenafil.

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