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ED most Effective pills
December 17, 2022
Posted by

Erectile dysfunction Pills

Erectile dysfunction (ED) is a treatable condition, and various medications can help, such as sildenafil and tadalafil. The pills that people find most effective will depend on their individual needs and lifestyles.

All Erectile Dysfunction pills are available via prescription only, so a person must first speak with a doctor or healthcare professional to discuss symptoms. Some companies offer telehealth consultations. The medical professional will then decide whether ED medication is appropriate.
Examples of ED pills include:

  • Sildenafil
  • Tadalafil
  • Avanafil
  • Vardenafil

Research Trusted Source shows that phosphodiesterase type 5 (PDE5) inhibitors can effectively treat ED, together with other medications, such as injections.

These drugs impede the functioning of PDE5, an enzyme within the blood vessel walls that helps control blood flow.

Following arousal, the body releases enzymes that cause blood vessels in the smooth muscles to relax, allowing for more blood flow. PDE5 inhibitors block the degradation of these enzymes, increasing blood flow and resulting in an erection.

It is important to note that a person needs to be aroused for a PDE5 inhibitor to help with ED.
This article focuses on PDE5 inhibitors. It discusses what erectile dysfunction is and what may cause it and looks at the common PDE5 medications for ED in detail.

Available PDE5 inhibitors for ED Medication

Below is detailed information about the PDE5 inhibitor drugs available.

Sildenafil (Viagra)

Sildenafil (Viagra) is common in the treatment of ED. It can also treat conditions such as pulmonary hypertension, a type of high blood pressure in the lungs.

The pills come in 25 mg, 50 mg, or 100 mg.

Some advantages of taking sildenafil for ED include:

  • Fast-acting: It starts working around 30 minutes after taking the pill.
  • Research: Clinical trials and studiesTrusted Sources confirm its effectiveness.
  • Lasting effects: Up to 4 hours.
  • Side effects: Serious side effects are rare, though they can include allergic reactions and heart problems.

Some disadvantages include:

  • Short-term use: It may only be a short-term option, as 20–50% of people who take sildenafil do so temporarily.
  • Unsuitable for some health conditions: Viagra’s prescribing information states people with cardiovascular diseases that make sexual activity unsafe should take Viagra with caution. This also applies to people with aortic stenosis, idiopathic hypertrophic subaortic stenosis, or those with severely impaired autonomic blood pressure control. The NHS states those with serious liver conditions, low blood pressure, multiple myeloma, or sickle cell anemia should speak with a doctor before taking Viagra.
  • Drug interactions: It can interact with other drugs, including some heart disease and blood pressure medications.
  • Preference: People seem to prefer an alternative drug called tadalafil, though the two drugs are equally effective, according to 2017 research.

There are also some possible side effects of sildenafil, including:

  • a stuffy or runny nose
  • hot flashes
  • headaches
  • a fever
  • nausea
  • chest pains
  • painful erections lasting several hours
  • dizziness
  • vision problems
  • indigestion

Where to buy sildenafil (Viagra) online?

The following companies offer sildenafil:

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Tadalafil (Cialis)

Tadalafil (Cialis) works by increasing blood flow to the penis. Doctors also use the drug to treat high blood pressure in the lungs and enlargement of the prostate. For ED, people take it as an oral tablet.
Some advantages of tadalafil include the following:

  • Longest lasting: It is the longest-lasting PDE5 drug for ED, typically lasting up to 36 hours, though some reports suggest it can last up to 72 hours.
  • Longer-term use: It is possible to take a low dose of 2.5–5 mg once per day for a longer-term solution.
  • Daily use: People who regularly engage in sexual activities may prefer taking a daily pill.
  • Increased confidence: Research suggests that people who take tadalafil experience more sexual confidence than those who do not.

However, the disadvantages include the factors below:

  • Cost: Taking it every day can have a higher cost.
  • Hidden underlying ED causes: Taking it long-term may prevent or delay treatment for the underlying cause of ED, which may be psychological.
  • Drug interactions: Tadalafil can interact with several types of medication, including common blood pressure drugs.

There are also possible side effects from tadalafil, including:

  • a stuffy or runny nose
  • hot flashes
  • indigestion
  • headaches
  • pain in the limbs
  • muscle pain
  • back pain

Where to buy tadalafil (Cialis)

Tadalafil is available to purchase from the following companies:

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Avanafil (Stendra)

Avanafil (Stendra) is another PDE5 drug. It works similarly to other drugs in its class by increasing blood flow to the penis.

Some advantages of avanafil include:

  • Fast-acting: Avanafil can start working 15–30 minutes after taking the drug.
  • Safe: ResearchTrusted Source has found that avanafil is a safe and effective ED treatment.
  • Longer lasting: Its effects can last up to 6 hours Trusted Source.

Popular with older and younger adults: An older review from 2014Trusted Source found that older and younger adults both preferred taking avanafil to other PDE5 drugs due to its quick effects.

However, a disadvantage of the drug is that it is currently unavailable in generic form, making it more expensive than other PDE5 drugs.

There are also some possible side effects of taking avanafil, including:

  • hot flashes
  • headaches
  • muscle aches
  • back pain
  • nausea
  • vision problems
  • dizziness
  • rash

Where to buy avanafil (Stendra)

The following companies offer avanafil (Stendra).

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Vardenafil (Levitra)

Similar to other PDE5 medications for ED, vardenafil (Levitra) works by increasing blood flow to the penis.

Some advantages of vardenafil include clinical trials finding it to be effective. In addition, unlike avanafil, vardenafil is available in a more affordable, generic form.

Its disadvantages are that the drug can take comparatively longer to start working, and a person needs to take it 1 hour before sexual activity. In addition, compared with tadalafil and sildenafil, vardenafil has no unique advantages.

Some possible side effects of vardenafil include:

  • a stuffy or runny nose
  • facial flushing
  • headaches
  • stomach problems
  • back pain
  • vision problems

Where to purchase vardenafil (Levitra)

Levitra and its generic version, vardenafil, are only available to purchase once a doctor has prescribed them.

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How to purchase ED drugs

People can purchase ED medications at a pharmacy, provided they have a valid prescription from a doctor or healthcare professional.

Alternatively, they can purchase them online, usually after completing an online questionnaire reviewed by a doctor or healthcare team.

Individuals should check reviews of the health company before purchasing a product and consult a doctor or pharmacist if they have any concerns.

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How well do ED pills work?

ResearchTrusted Source suggests that ED pills are safe and effective when someone takes them under a doctor’s supervision.

Results may vary between individuals, but a 2021 review found that 50 mg and 100 mg sildenafil pills were most effective compared to a placebo. However, there is currently insufficient data to compare the different PDE5 inhibitor pills.

How to take ED pills

ED pills are typically taken around 1 hour before sex. However, instructions may vary between medications.

Some pills require people to take them with food, and other pills on an empty stomach.

A person should always follow the instructions before taking any prescription medication.

Alternative ED medications

While ED medications are often effective, some individuals may prefer to try other methods of ED treatment, including Trusted Source:

Diet, exercise, and healthy habits: This involves staying active, following a nutritious diet, and avoiding smoking.

  • Psychotherapy: Dealing with underlying emotional or psychological issues may help ease ED.
  • Vacuum devices: These devices use suction to bring blood into the penis to achieve an erection.
    ED rings: These devices use constriction to maintain an erection. A person puts this device around the base of their penis. An example of this is Eddie by Giddy. The product comes in different sizes, and the website provides full instructions. Learn more about the Eddie product here.
  • Surgery: When all other treatments are ineffective, a doctor may recommend a surgical implant to help a person achieve or maintain their erections.

Read about some of the best available ED rings.

When to contact a doctor

Individuals should keep regular contact with their doctor if they experience prolonged ED, as there may be an underlying health condition that needs exploration.

After taking ED pills, a person may experience side effects such as headaches, indigestion, dizziness, or a stuffy nose. These are common and usually subside over time.

However, a person should consult their doctor if these side effects become severe or persistent.

Although rare, ED medications can also cause more serious side effects, including:

  • chest pain
  • vision problems
  • hearing loss
  • seizures
  • skin reactions, including itchy, red, or swollen skin
    priapism, a painful erection lasting more than 4 hours

If someone experiences any of these side effects, they should discontinue using the drug immediately and seek medical advice.

Symptoms, such as wheezing, tightness in the chest or throat, difficulty breathing, and swelling of the mouth, throat, lips, or tongue, may have links with anaphylaxis, a life-threatening allergic reaction.
If a person notices any symptoms of anaphylaxis, they should call 911 or go to the nearest emergency room.

General Frequently Asked Questions

Here are some common questions about ED and its medications.

Q.1 What causes ED?

ED can develop due to several mental or emotional issues, including trusted Source stress, anxiety, depression, and relationship issues.

There are also many physical causes of ED, such as heart disease, diabetes, multiple sclerosis, and high blood pressure or cholesterol levels. Smoking tobacco, consuming high amounts of alcohol, and taking certain medications could also contribute to the condition.

Q.2 How do you know whether ED is physical or mental?

A doctor or healthcare professional can determine whether a person’s ED is due to physical or mental health factors by collecting information about their medical and sexual history. They may also conduct a physical exam.

Healthcare professionals may also recommend an overnight erection test, which involves placing a device around the penis overnight to measureTrusted Source the number of nocturnal erections. If a person can achieve a set number of erections at night, it may indicate that their ED is due to psychological problems rather than physical conditions.

A person may also undergo an intracavernosal test. During this test, doctors inject a small amount of medication into the base of the penis to cause an erection. Imaging techniques, such as an ultrasound, can also help determine whether there are any problems with blood flow.

Q.3 How much do pills for ED cost?

To get a pill for ED, a person needs a prescription from a doctor or an online telehealth service. Once the prescription is ready, the cost will depend on whether an individual’s insurance plan covers all or some of the costs.

Typically, generic versions of ED pills, such as sildenafil, cost significantly less than the brand-name versions, such as Viagra.

Q.4 How effective are ED medications?

Each of the medications in this article is effective in treating ED. However, according to research trusted Sources, avanafil may be the fastest-working medication with the fewest visual side effects.
It is important to note that for any of these medications to work, a person requires sexual stimulation.

Q.5 Which ED medication is best?

The type of ED medication a person should take depends on individual needs. Each medication type may have different side effects, dosage requirements, and times to work properly.
Individuals should consider these factors before trying these medications.

Q.6 Which ED drug is safest?

All four of the main ED pills — sildenafil (Viagra), tadalafil (Cialis), vardenafil (Levitra), and avanafil (Stendra) — are safe for most people to use. These drugs are FDA-approved for use in ED. A person must ensure their medication is doctor-prescribed and comes from a legitimate source.

Q.7 Is it safe to combine ED treatments?

Health experts recommend against combining ED medications unless a doctor advises otherwise.
If one medication for ED is not working, a person should consult their doctor to determine whether alternative treatment options may work better or if other underlying factors may contribute to ED.

Q.8 What is the most popular ED pill?

The most commonly prescribed erectile dysfunction medications are sildenafil (Viagra) and tadalafil (Cialis).

Q.9 Can you get ED medications over the counter?

Most ED medications require a prescription from a doctor. However, people can buy ED devices such as vacuums and rings online.

Q.10 Which is the best pharmacy to buy ED Medications?

According to the user’s rating, www.genericmedlife.com is the best online pharmacy for buying ED medications like sildenafil, avanafil, vardenafil, etc.


Several medications can treat ED, and many drugs — including those in this article — work by blocking the PDE5 enzyme, increasing blood flow to the penis.

The best choice of ED medication will depend on various factors. For example, people who have regular sex may prefer taking tadalafil, which is available as a daily pill. Meanwhile, others may prefer medications they can take just before having sex, such as sildenafil, avanafil, or vardenafil.
However, it is important for a person to consult a doctor before taking ED medication and only use it as directed to help prevent adverse side effects.

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